Spravato is a prescription medicine administered as a nasal spray, alongside your oral antidepressant, for treatment-resistant depression (TRD).

If you have struggled with depression and tried two or more antidepressants without relief, you might have treatment-resistant depression. Call our office to make an appointment at (618) 315-6466.

How to get started with SPRAVATO?

You can expect the following when getting started with Spravato:

  • Make an appointment by calling (618) 315-6466
  • We review your medical and depression treatment history. Please disclose any history of substance abuse, including prescription drugs, street drugs, or alcohol.
  • We will consider the possibility of incorporating Spravato into your treatment plan.
  • Understand that the treatment won’t start on your initial visit; the healthcare provider at our certified Spravato treatment center will first conduct their assessment to determine if you’re a suitable candidate for Spravato.
  • If you are a suitable candidate, you will be asked to provide your insurance information for SPRAVATO coverage and prior authorization.
  • If you are a suitable candidate, you’ll be asked to fill out enrollment and screening forms.
  • After your insurance approval, you’ll be called to schedule a follow-up visit.

SPRAVATO is indicated for:

  • Adults with treatment-resistant depression (TRD)
  • Adults with major depressive disorder (MDD) and acute suicidal ideation or behavior

How can I get SPRAVATO?

Spravato is exclusively accessible at certified Spravato treatment centers under the guidance of healthcare providers. Due to the risks of side effects, abuse, and misuse:

  • We enroll you in the Spravato Risk Evaluation and Mitigation Strategy (REMS) Program.
  • We observe you for two or more hours after each treatment for your safety.

What are the contraindications?

You may not be a suitable candidate if you have had the following medical conditions:

  • Blood vessel disease (Aneurysm)
  • An abnormal connection between your blood vessels (Arteriovenous malformation)
  • A history of bleeding in the brain
  • Allergies to esketamine, ketamine, or any other ingredients in the Spravato nasal spray

How should I prepare for the treatment Days?

Guidelines for your treatment days:

  • Plan your rides to and from our clinic.
  • Refrain from driving, operating machinery, or any task requiring full alertness until the day after treatment, following a restful sleep.
  • Bring a book, a relaxing playlist, or other forms of entertainment for the session because our team will monitor you for at least two hours after your session.
  • Avoid eating two hours before taking Spravato.
  • Avoid drinking liquids 30 minutes before taking Spravato.
  • If you take any nasal corticosteroids or nasal decongestants, take these medicines at least one hour before your session.

How do I use SPRAVATO?

You will administer Spravato yourself under the supervision of our healthcare provider at our treatment center, who will guide you on how to use the Spravato nasal spray device.

Please note, that you will not be allowed to take home the SPRAVATO nasal spray.

What are the side effects of SPRAVATO?

Common side effects that can occur during and after taking Spravato include:

  • Feeling disconnected from yourself, thoughts, feelings, space & time (Dissociation)
  • Dizziness
  • Nausea
  • Sleepiness (Sedation)
  • Spinning sensation
  • Reduced sense of touch and sensation
  • Anxiety
  • Lack of energy
  • Increased blood pressure
  • Vomiting
  • Feeling drunk
  • Risk of suicidal thoughts & behavior

How often do I need to take SPRAVATO?

You’ll take Spravato twice a week for the first month. In the second month, you’ll take it once a week. Following that, it’s once a week or once every two weeks, determined by your healthcare provider. It’s important to continue taking your oral antidepressant as prescribed.

For more information, visit SPRAVATO website: https://www.spravato.com/

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